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Abstract Background: Results: To address these issues, we introduce a novel adaptive semi-quantitative group testing (SQGT) scheme to e ciently screen populations via two-stage qPCR testing. The SQGT method quantizes cycle threshold (Ct) values into multiple bins, leveraging the information from the rst stage of screening to improve the detection sensitivity. Dynamic Ct threshold adjustments mitigate dilution e ects and enhance test accuracy. Comparisons with traditional binary outcome GT methods show that SQGT reduces the number of tests by 24% on the only complete real-world qPCR group testing dataset from Israel, while maintaining a negligible false negative rate. Conclusion: In conclusion, our adaptive SQGT approach, utilizing qPCR data and dynamic threshold adjustments, o ers a promising solution for e cient population screening. With a reduction in the number of tests and minimal false negatives, SQGT holds potential to enhance disease control and testing strategies on a global scale. Keywords: Group testing, Pooled testing, Semiquantitative group testing, qPCR, Ct values, Viral load, COVID-19 

We continue a line of work on extracting random bits from weak sources that are generated by simple processes. We focus on the model of locally samplable sources, where each bit in the source depends on a small number of (hidden) uniformly random input bits. Also known as local sources, this model was introduced by De and Watson (TOCT 2012) and Viola (SICOMP 2014), and is closely related to sources generated by AC⁰ circuits and bounded-width branching programs. In particular, extractors for local sources also work for sources generated by these classical computational models. Despite being introduced a decade ago, little progress has been made on improving the entropy requirement for extracting from local sources. The current best explicit extractors require entropy n^{1/2}, and follow via a reduction to affine extractors. To start, we prove a barrier showing that one cannot hope to improve this entropy requirement via a black-box reduction of this form. In particular, new techniques are needed. In our main result, we seek to answer whether low-degree polynomials (over 𝔽₂) hold potential for breaking this barrier. We answer this question in the positive, and fully characterize the power of low-degree polynomials as extractors for local sources. More precisely, we show that a random degree r polynomial is a low-error extractor for n-bit local sources with min-entropy Ω(r(nlog n)^{1/r}), and we show that this is tight. Our result leverages several new ingredients, which may be of independent interest. Our existential result relies on a new reduction from local sources to a more structured family, known as local non-oblivious bit-fixing sources. To show its tightness, we prove a "local version" of a structural result by Cohen and Tal (RANDOM 2015), which relies on a new "low-weight" Chevalley-Warning theorem.